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Transepidermal water loss in allergic diseases
Serdar Al1, Suna Asilsoy2, Ozge Atay3
1From the Department of Pediatric Allergy and Clinical Immunology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
Allergy and Asthma Proceedings
|May 10, 2023
Summary
Children with atopic diseases have higher transepidermal water loss (TEWL) than healthy children, supporting the epithelial barrier hypothesis. Higher TEWL may indicate increased risk for allergic conditions.
Area of Science:
- Dermatology
- Allergology
- Pediatrics
Background:
- The epithelial barrier hypothesis is increasingly recognized in allergic disease development.
- Transepidermal water loss (TEWL) is a measure of skin barrier function.
- Limited research exists on TEWL in the context of allergic diseases.
Purpose of the Study:
- To investigate the relationship between atopic diseases and TEWL.
- To compare TEWL in children with atopic conditions versus healthy controls.
- To explore the association between hygiene habits and TEWL in these groups.
Main Methods:
- The study included 182 patients with atopic diseases (asthma, allergic rhinitis, food allergy, atopic dermatitis) and healthy children.
- TEWL was measured using a validated open room system under controlled environmental conditions.
- Participants reported bathing frequency and cleaning product usage.
Main Results:
- Patients with atopic diseases exhibited significantly higher median TEWL (21.3 g/hm²) compared to controls (9.6 g/hm²).
- The atopic disease group reported a higher frequency of weekly baths.
- A TEWL cutoff of 13.2 g/hm² demonstrated high sensitivity (83.2%) and specificity (84.3%) for identifying atopic diseases.
Conclusions:
- Elevated TEWL in atopic diseases supports the epithelial barrier hypothesis in disease pathogenesis.
- TEWL measurement shows potential as a method for identifying individuals at risk for atopic conditions.
- Further research is needed to establish precise thresholds and explore factors influencing TEWL and reduction strategies.
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