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Updated: Jul 31, 2025

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Reduced plasma coagulation factor XIII in patients with acute leukemia in remission during consolidation chemotherapy

Xia-Ye Lv1,2, Zi-Jian Li3

  • 1Department of Hematology, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, China.

Annals of Hematology
|May 10, 2023
PubMed

Acute leukemia (AL) is a malignancy from hematologic stem cells (HSC). Consolidation with intensive chemotherapy is required after induced remission and repeatedly causes treatment-related bleeding that is usually attributed to chemotherapy-induced thrombocytopenia (CIT). However, our previous study demonstrated that severe deficiency of plasma coagulation factor XIII (pFXIII) also participated in the bleeding of CIT in AL. However, the relationship between pFXIII deficiency and consolidation chemotherapy was unknown. Here, we observed the concentration of pFXIII in patients with AL before and after consolidation chemotherapy and reevaluated the correlation to bleeding in myelosuppression. Thus, we found that the concentration of pFXIII before chemotherapy in all patients was markedly lower than in the control data and was further decreased by chemotherapy, related to bleeding in myelosuppression. These findings indicated that chemotherapy-induced pFXIII deficiency should be of concern and explored in depth.

Keywords:
Acute leukemiaBleedingChemotherapy-induced thrombocytopeniaConsolidation chemotherapyPlasma FXIII

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