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Preparation of pH sensitive bacteriostatic W/O/W emulsion microcapsules
XiaoNan Zhang1, WenQin Xu1, Xing Li1
1College of Material Science and Engineering, Guilin University of Technology, Guilin, China.
Journal of Biomaterials Science. Polymer Edition
|May 10, 2023
Summary
This study developed novel pH-responsive, sustained-release bacteriostatic microcapsules using zeolite molecular sieves to enhance drug loading and control release of potassium diformate. These microcapsules show significant antibacterial effects against common pathogens.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Biotechnology
Background:
- Non-antibiotic drugs offer alternatives for combating bacterial infections.
- Controlled drug delivery systems are crucial for improving therapeutic efficacy and patient compliance.
- Zeolite molecular sieves can act as effective drug carriers and release modifiers.
Purpose of the Study:
- To prepare and characterize W/O/W emulsion microcapsules for sustained release of potassium diformate.
- To investigate the role of zeolite molecular sieves in enhancing drug encapsulation and controlling release kinetics.
- To evaluate the bacteriostatic efficacy of the developed microcapsules against pathogenic bacteria.
Main Methods:
- Preparation of W/O/W emulsion microcapsules using pectin-calcium, xanthan gum, and chitosan.
- Incorporation of zeolite molecular sieve as a drug-binding effector for potassium diformate.
- Characterization using FTIR, TGA, SEM, TEM, and permeance experiments.
- In vitro drug release studies and kinetic analysis (first-order, Ritger-Peppas).
- Bacteriostasis experiments against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis.
Main Results:
- Successfully fabricated pH-responsive W/O/W emulsion microcapsules with distinct phases.
- Zeolite molecular sieve incorporation significantly improved encapsulation efficiency (12.31%) and drug loading (61.55%).
- Sustained drug release observed, following first-order and Ritger-Peppas kinetic models.
- High antibacterial rates achieved: 97.25% against E. coli, 94.05% against S. aureus, and 95.93% against B. subtilis.
Conclusions:
- The developed composite emulsion microcapsules effectively encapsulate and provide sustained release of potassium diformate.
- Zeolite molecular sieves enhance the performance of the drug delivery system.
- These microcapsules demonstrate significant potential as a novel controlled-release bacteriostatic agent for in vivo applications.
