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Simultaneous quantification of serum albumin and gamma globulin using Zn(II)-metallosurfactant via a coffee ring
Aastha1, Priyanka1, Subhabrata Maiti1
1Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, Manauli 140306, India. smaiti@iisermohali.ac.in.
Abstract:
Herein, we report interactivity and conjugate formation ability between a Zn(II)-metallosurfactant and two clinically relevant serum proteins, albumin (ALB) and γ-globulin (GGB). We found that the surfactant-ALB conjugate promotes coffee ring formation, whereas with GGB it gets suppressed, which is due to the difference in structural anisotropy and hydrophobicity of the conjugates. Additionally, validation of this biosensing platform has been established in human serum samples, and it has potential applications for on-spot rapid diagnostics in remote areas.
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