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SARS-CoV-2 Infection in Children with Idiopathic Nephrotic Syndrome: A Multicentric Study
Sanya Chopra1, Sumantra Raut2, Rajiv Sinha3
1Department of Pediatric Nephrology, Lady Hardinge Medical College (LHMC) and associated Kalawati Saran Children Hospital, New Delhi.
Indian Pediatrics
|May 10, 2023
Summary
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) in children with difficult-to-treat idiopathic nephrotic syndrome poses high risks. This patient group experienced increased acute kidney injury and mortality.
Area of Science:
- Pediatric Nephrology
- Infectious Diseases
- Critical Care Medicine
Background:
- Idiopathic nephrotic syndrome (INS) is a primary glomerulopathy in children.
- The impact of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection on pediatric INS is not well-defined.
- Certain pediatric nephrotic syndrome cases are refractory to standard treatments, posing management challenges.
Purpose of the Study:
- To investigate the clinical spectrum and outcomes of children with idiopathic nephrotic syndrome who also tested positive for SARS-CoV-2.
- To identify risk factors and high-risk subgroups within this population.
Main Methods:
- A multicenter retrospective study design.
- Inclusion of 30 pediatric patients with confirmed SARS-CoV-2 infection and a diagnosis of idiopathic nephrotic syndrome.
- Analysis of clinical data, treatment responses, and patient outcomes.
Main Results:
- Children with difficult-to-treat idiopathic nephrotic syndrome represented a high-risk group.
- A significant incidence of acute kidney injury was observed in this cohort.
- Elevated mortality rates were documented among these patients.
Conclusions:
- SARS-CoV-2 infection in children with difficult-to-treat idiopathic nephrotic syndrome is associated with severe complications.
- Prompt recognition and management strategies are crucial for improving outcomes in this vulnerable pediatric population.
- Further research is warranted to elucidate the pathophysiology and optimize treatment protocols.
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