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Related Experiment Video

Updated: Jul 31, 2025

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis
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Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

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Pathways that affect anterior morphogenesis in C. elegans embryos.

Balasubramaniam Boopathi1, Irini Topalidou2, Melissa Kelley1

  • 1Department of Molecular Biology, College of Agriculture, Life Sciences and Natural Resources, University of Wyoming, Laramie, Wyoming, United States of America.

Biorxiv : the Preprint Server for Biology
|May 10, 2023
PubMed
Summary
This summary is machine-generated.

Researchers identified new proteins involved in the embryonic apical extracellular matrix (aECM) in Caenorhabditis elegans. SYM-3/FAM102A and SYM-4/WDR44 proteins traffic together but do not regulate aECM deposition.

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Related Experiment Videos

Last Updated: Jul 31, 2025

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Tracking and Quantifying Developmental Processes in C. elegans Using Open-source Tools
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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Extracellular Matrix Biology

Background:

  • The embryonic epidermis secretes an apical extracellular matrix (aECM) crucial for stabilizing the epidermis during Caenorhabditis elegans morphogenesis.
  • Mechanical forces during development can deform the epidermis, highlighting the importance of aECM integrity.

Conclusions:

  • SYM-3/FAM102A and SYM-4/WDR44 are involved in intracellular trafficking pathways within the context of apical ECM biology.
  • These proteins do not appear to directly regulate the deposition of key apical ECM components.
  • New insights into the complex pathways governing embryonic morphogenesis and aECM regulation were gained.