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    The actin-binding protein synaptopodin is essential for intracellular bacteria to spread between cells. It helps organize actin tails, promoting the formation and stability of cellular protrusions required for pathogen dissemination.

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    Area of Science:

    • Microbiology
    • Cell Biology
    • Pathogen-Host Interactions

    Background:

    • Intracellular pathogens utilize intercellular spread for dissemination, a process dependent on actin cytoskeleton dynamics.
    • Pathogen-induced actin polymerization drives the formation of cellular protrusions for cell-to-cell movement.
    • Mechanisms by which pathogens manipulate host actin for efficient spread remain incompletely understood.

    Conclusions:

    • Synaptopodin is a critical host factor enabling intracellular bacteria to efficiently spread between epithelial cells.
    • The protein reprograms the host actin cytoskeleton to facilitate protrusion formation and pathogen dissemination.
    • These findings highlight a novel cellular function for synaptopodin in pathogen virulence and host-pathogen interactions.