A Biosensing Platform Based on Metamaterials BioNEMS for Lab-on-Chip Systems.
IEEE Transactions on Nanobioscience
|May 10, 2023
Summary
This study introduces a novel label-free biosensor using optical nanoelectromechanical systems (Bio-NEMS) and split-ring resonator (SRR) metamaterials. The device detects biological changes by measuring shifts in plasmon resonance wavelength, enabling sensitive and quantitative analysis.
Area of Science:
- Optoelectronics
- Nanotechnology
- Biomedical Engineering
Background:
- Label-free biosensing is crucial for early disease diagnosis and drug discovery.
- Existing biosensors often face limitations in sensitivity and specificity.
- Nanoelectromechanical systems (NEMS) offer miniaturization and high sensitivity potential.
Purpose of the Study:
- To develop and characterize a novel label-free biosensor platform.
- To utilize split-ring resonator (SRR) metamaterials integrated with a Bio-NEMS transducer.
- To enable sensitive detection of biological analytes through optical resonance shifts.
Main Methods:
- Fabrication of a flexible Bio-NEMS transducer supporting SRR metamaterial cells.
- Functionalization of the NEMS beam surface for specific bio-interactions.
- Monitoring changes in the air gap distance between metamaterial cells due to surface stress.
- Measuring shifts in the plasmon resonance wavelength in response to analyte binding.
Main Results:
- Achieved a detection sensitivity of 4251 nm/RIU.
- Obtained a figure of merit (FOM) of 500.1 RIU⁻¹.
- Demonstrated a mechanical sensitivity of [Formula: see text]/Nm⁻¹ and a resonant frequency of 17.1 kHz.
Conclusions:
- The proposed SRR metamaterial-based Bio-NEMS platform is highly effective for label-free biosensing.
- The device offers high sensitivity and quantitative detection capabilities for target analytes.
- This technology holds significant potential for accurate disease diagnosis and drug identification.
