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Cardiac System during the Aging Process

Ana Sofia Fernandes Ribeiro1, Blanca Egea Zerolo1, Fidel López-Espuela2

  • 1Escuela de Enfermería y Fisioterapia San Juan de Dios. Universidad Pontificia Comillas, Madrid, Spain.

Aging and Disease
|May 10, 2023
PubMed

Insights

Cardiac aging leads to system decline and increased heart disease risk. Understanding these changes is key to developing strategies for healthier aging in the elderly.

Area of Science:

  • Cardiology
  • Gerontology
  • Molecular Biology

Background:

  • The aging process significantly impacts cardiac function, leading to disruptions in homeostasis.
  • Aging is a primary risk factor for cardiovascular diseases, including heart failure and mortality.

Purpose of the Study:

  • To provide a comprehensive overview of cardiac aging.
  • To explore structural, functional, and cellular changes in the aging heart.
  • To examine the role of genetics, epigenetics, and exercise in cardiac aging.

Main Methods:

  • Literature review focusing on cardiac aging.
  • Analysis of structural and functional modifications.
  • Investigation of cellular mechanisms of cardiac dysfunction.
  • Examination of genetic and epigenetic factors.
  • Review of exercise response in the aging heart.

Main Results:

  • Aging induces progressive structural and functional declines in the heart.
  • Cellular mechanisms underlying age-related cardiac dysfunction are multifaceted.
  • Genetic and epigenetic factors play a crucial role in the development of cardiac diseases with age.
  • The aging heart exhibits altered responses to physiological stimuli like exercise.

Conclusions:

  • Understanding cardiac aging is vital for preventing age-related cardiovascular events.
  • Targeting the aging process can improve the quality of life for the elderly population.
  • Further research into cardiac aging mechanisms can inform therapeutic strategies.

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