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Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis

Peter Falkai1,2, Moritz J Rossner1, Florian J Raabe1

  • 1Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian University, Munich, Germany.

Schizophrenia Bulletin
|May 10, 2023
PubMed
Summary

Schizophrenia impairs cognition due to brain disconnectivity. Combining pro-myelinating drugs with exercise may restore myelin plasticity, improving frontotemporal connectivity and cognitive function in patients.

Keywords:
cognitionhippocampusmyelinationoligodendrocyte precursor cellsoligodendrocytesprefrontal cortex

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