Upconversion nanoparticles anchored MnO₂ nanosheets for luminescence "turn on" detecting hydrogen peroxide

The sensitively and reliably detecting hydrogen peroxide (H₂O₂) is of significant for biology and environment protection fields. Herein, we reported a high sensitive H₂O₂ nanoprobe based on upconversion nanoparticles (UCNPs) anchored MnO₂ nanosheets. In which, DNA modified NaYF₄@NaYF₄:Yb,Tm core-shell nanoparticles were anchored onto the MnO₂ nanosheets surface via π-π stacking. Owing to the luminescence resonance energy transfer, the blue luminescence of UCNPs was effectively quenched by MnO₂ nanosheets, then the luminescence could be restored by adding H₂O₂ for reducing MnO₂ to Mn²⁺, and achieving a H₂O₂ concentration-dependent luminescence change, the detection limit could reach to 0.23 nM (S/N = 3). The proposed method could detect H₂O₂ in serum, lake water and real samples. Thus, a desired upconversion luminescence sensing strategy for detection H₂O₂ in life and environmental analysis was successfully constructed. It may be provide a potential tool in disease diagnosis and environmental monitoring fields.