Related Experiment Video
Updated: Jul 31, 2025

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning
Published on: January 19, 2022
To loop or not to loop? CNS-28 is the answer
Aaron Yang1, Amanda C Poholek1
1Division of Pediatric Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Abstract:
Regulation of interferon-γ is critical to constrain inflammation and mount effective responses to infection and anti-tumor immunity. In this issue of Immunity, Cui et al. identify a distal silencer element that disrupts promoter-enhancer looping, regulating IFN-γ expression and preventing inappropriate inflammation.
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