Related Experiment Video
Updated: Jul 31, 2025

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Generation and Culturing of Primary Human Keratinocytes from Adult Skin
Published on: December 22, 2017
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When SLC46A2 delivers cargo into keratinocytes
1Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, P.R. China.
Immunity
|May 10, 2023
Abstract:
How pattern recognition receptors NOD1 and NOD2 sense bacterial muropeptides from extracellular bacteria to drive keratinocyte inflammation remains unclear. In this issue of Immunity, Bharadwaj et al. show that the solute carrier 46A2 (SLC46A2) delivers DAP-muropeptides into the cytosol to drive NOD1 activation in keratinocytes and elicit skin inflammation during psoriasis.

