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Smartphone-based diagnostics for biosensing infectious human pathogens.

Aditya Amrut Pawar1, Sanchita Bipin Patwardhan1, Sagar Barage2

  • 1Amity Institute of Biotechnology, Amity University Maharashtra, Mumbai-Pune Expressway, Bhatan, Panvel, Mumbai, Maharashtra, 410206, India.

Progress in Biophysics and Molecular Biology
|May 10, 2023
PubMed
Summary

Smartphone biosensors offer rapid disease diagnosis, especially in resource-limited areas. This review covers their use in detecting infectious pathogens like viruses and bacteria using various sensing methods.

Keywords:
BiosensorsCOVID-19DetectionDiagnosisHuman pathogensSmartphone

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Area of Science:

  • Biomedical Engineering
  • Infectious Disease Diagnostics
  • Mobile Health Technology

Background:

  • Smartphones are ubiquitous, offering powerful, user-friendly platforms for data access and processing.
  • Their potential in public health diagnostics is significant, especially in resource-limited settings as point-of-care tools.
  • Integration with sensors enables rapid disease detection, visualization, data collection, and transfer.

Purpose of the Study:

  • To critically review smartphone-based biosensors for diagnosing infectious human pathogens.
  • To discuss various analytical sensing methods employed by these biosensors.
  • To analyze diagnostic strategies and performance for pathogen detection.

Main Methods:

  • Review of literature on smartphone-based biosensors for infectious disease diagnosis.
  • Analysis of biosensing methods including microscopic imaging, instrumental interface, colorimetric, fluorescence, and electrochemical techniques.
  • Evaluation of diagnostic performance and strategies for pathogen identification.

Main Results:

  • Smartphone biosensors effectively detect and diagnose diseases caused by viruses, bacteria, and fungi.
  • Diverse analytical sensing methods are utilized, showcasing versatility in pathogen detection.
  • These systems demonstrate potential for rapid, point-of-care diagnostics.

Conclusions:

  • Smartphone-based biosensors are a promising technology for infectious disease diagnosis, particularly in underserved regions.
  • Continued development of these biosensors can enhance global public health surveillance and response.
  • Future perspectives focus on improving analytical performance and expanding applications.