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Related Experiment Video

Updated: Jul 31, 2025

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Patient-Reported Outcomes After Tetralogy of Fallot Repair.

Adrienne H Kovacs1, Gerald Lebovic2, Stavroula Raptis2

  • 1Equilibria Psychological Health, Toronto, Ontario, Canada; Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Journal of the American College of Cardiology
|May 10, 2023
PubMed
Summary
This summary is machine-generated.

Patient-reported outcomes like quality of life are crucial for assessing tetralogy of Fallot (TOF) care. Older patients with TOF reported lower health status and more mobility issues, highlighting areas for improved interventions.

Keywords:
patient-reported outcomesquality of lifetetralogy of Fallot

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Area of Science:

  • Cardiology
  • Patient-Reported Outcomes
  • Congenital Heart Disease

Background:

  • Comprehensive assessment of tetralogy of Fallot (TOF) outcomes requires evaluating patient-reported outcomes (PROs), including quality of life (QOL) and health status (HS), beyond traditional morbidity and mortality metrics.
  • Understanding PROs in adolescents and adults with repaired TOF is essential for holistic patient care.

Purpose of the Study:

  • To explore PROs in adolescents and adults with repaired tetralogy of Fallot (TOF).
  • To identify variables associated with patient-reported outcomes (PROs) in this population.

Main Methods:

  • A cross-sectional observational study was conducted within a prospective registry of repaired TOF patients with moderate or greater pulmonary regurgitation.
  • Participants (N=607) from North America, Europe, and Asia completed QOL and HS visual analogue scales.
  • Data were analyzed across age cohorts: <18, 18-25, 26-40, and >40 years.

Main Results:

  • Median QOL scores were similar across age groups, but median HS scores were lowest in the oldest cohort (>40 years).
  • Older patients reported increased mobility issues and pain/discomfort.
  • Asymptomatic status (functional class I) was strongly associated with superior QOL and HS measures, alongside being White, nonsyndromic, employed, and having better left ventricular function.

Conclusions:

  • Improving TOF outcomes necessitates integrating PROs with conventional clinical assessments.
  • Addressing factors linked to poorer PROs offers opportunities for targeted interventions to enhance the well-being of individuals with TOF.