Related Experiment Video
Updated: Jul 31, 2025

06:39
Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
15.8K
Acute Heart Failure Due to Multi-vessel Coronary Spasm
Hiroki Teragawa1, Ayaka Shirai2, Chikage Oshita1
1Department of Cardiovascular Medicine, JR Hiroshima Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|May 10, 2023
Summary
Coronary artery spasm can cause heart failure with preserved ejection fraction (HFpEF), even without significant blockages. This finding highlights the importance of considering coronary spasm in heart failure diagnoses.
Area of Science:
- Cardiology
- Internal Medicine
- Cardiovascular Research
Background:
- Heart failure with preserved ejection fraction (HFpEF) presents diagnostic challenges, often lacking clear obstructive coronary artery disease.
- Myocardial enzyme levels, ECG, and echocardiography can be normal in some HFpEF patients, necessitating further investigation.
Observation:
- A 46-year-old male presented with chest pain, dyspnea, and cough, initially diagnosed with HFpEF based on chest radiography showing congestion.
- Despite initial improvement with diuretics, coronary angiography revealed no significant stenosis, but a spasm provocation test confirmed multi-vessel coronary artery spasm.
Findings:
- The patient's symptoms were attributed to diffuse coronary artery spasms, not typical atherosclerotic narrowing.
- This case demonstrates that coronary artery spasm can be a primary cause of HFpEF.
Implications:
- Coronary artery spasm should be considered a critical differential diagnosis in patients presenting with heart failure, particularly HFpEF.
- Spasm provocation testing may be crucial for diagnosing HFpEF in the absence of obstructive coronary artery disease.
Related Concept Videos
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Pathophysiology of Heart Failure
1.7K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.7K
Cardiomyopathy II: Dilated Cardiomyopathy
12
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
12
Heart Failure I: Introduction
26
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
26
Heart Failure II: Pathophysiology
18
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
18
Heart Failure III: Clinical Manifestations
28
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
28

