Related Experiment Video

Updated: Jul 30, 2025

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
09:12

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

Published on: February 3, 2023

2.6K

Comparison of severity and prognosis of jaundice due to Rh incompatibility and G6PD deficiency

Maryam Zakerihamidi1, Ali Moradi2, Hassan Boskabadi3

  • 1Department of Midwifery, School of Medical Sciences, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|May 10, 2023
PubMed

Insights

Infantile jaundice due to Rh incompatibility or G6PD deficiency has similar poor prognoses. Higher bilirubin levels significantly impact infant outcomes, but early exchange transfusion can improve results.

Area of Science:

  • Neonatal Medicine
  • Pediatric Hematology
  • Clinical Pediatrics

Background:

  • Untreated infantile hyperbilirubinemia can lead to Kernicterus Spectrum Disorder.
  • Rhesus (Rh) incompatibility and glucose-6-phosphate dehydrogenase (G6PD) deficiency are significant causes of neonatal jaundice.
  • Defining prognosis in jaundiced infants with these conditions is crucial for timely intervention.

Purpose of the Study:

  • To compare the severity and 24-month prognosis of neonatal jaundice in infants with Rh incompatibility versus G6PD deficiency.
  • To evaluate the role of initial bilirubin levels in determining the long-term outcome for these infants.
  • To assess the impact of specific interventions on prognosis.

Main Methods:

  • A cohort study included 144 jaundiced infants (bilirubin > 20 mg/dl) aged 2-14 days.
  • Infants were categorized by cause: Rh incompatibility (85) or G6PD deficiency (59).
  • A 24-month follow-up included Denver II testing to assess developmental prognosis; bilirubin levels were compared at admission.

Main Results:

  • Infants with Rh incompatibility and G6PD deficiency showed similar bilirubin levels at admission for poor prognoses (36.23 ± 5.08 mg/dl vs. 37.96 ± 9.25 mg/dl).
  • Poor prognosis rates were comparable: 47% for Rh incompatibility and 56% for G6PD deficiency.
  • Higher initial bilirubin levels significantly correlated with poorer outcomes in both groups (P < 0.0001).

Conclusions:

  • Neonatal jaundice caused by G6PD deficiency carries a prognosis as poor as that from Rh incompatibility.
  • The severity of hyperbilirubinemia is a critical determinant of infant prognosis in both conditions.
  • Exchange transfusion for bilirubin levels < 25 mg/dl may enhance prognosis, particularly in Rh-incompatible infants.
Abstract

Keywords:
Blood group incompatibilityGlucose-6-phosphate dehydrogenase deficiencyHyperbilirubinemiaJaundiceNeonatalPrognosis

More Related Videos

In Vitro Enzyme Measurement to Test Pharmacological Chaperone Responsiveness in Fabry and Pompe Disease10:16

In Vitro Enzyme Measurement to Test Pharmacological Chaperone Responsiveness in Fabry and Pompe Disease

Published on: December 20, 2017

8.1K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.6K

Related Concept Videos

Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.6K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
740
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.0K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
207