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[Does halothane, in subnarcotic dosage, have a detectable broncholytic effect?].

A Gerking, C Ebert, B Precht

    Zeitschrift Fur Erkrankungen Der Atmungsorgane
    |January 1, 1986
    PubMed
    Summary
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    Subnarcotic halothane effectively reduces respiratory rate and resistance in patients with chronic obstructive pulmonary disease. This anesthetic agent demonstrates a significant bronchodilating effect, improving breathing in patients with severe bronchial obstruction.

    Area of Science:

    • Anesthesiology
    • Pulmonology
    • Pharmacology

    Context:

    • Chronic obstructive pulmonary disease (COPD) presents significant challenges due to bronchial obstruction.
    • Conventional therapies may be insufficient for acute exacerbations.

    Purpose:

    • To evaluate the efficacy of subnarcotic halothane in patients with chronic obstructive pulmonary disease and bronchial obstruction.
    • To assess halothane's bronchodilating and bronchospasmolytic effects.

    Summary:

    • Subnarcotic halothane (0.25-0.5 Vol.-%) was administered to 32 patients with COPD, 26 exhibiting increased respiratory resistance.
    • Significant reductions in respiratory rate and resistance, alongside increased tidal volume, were observed, indicating a bronchodilating effect.
    • In 10 patients with severe acute bronchial obstruction unresponsive to conventional treatment, subnarcotic halothane led to subjective and objective improvements, attributed to its bronchospasmolytic action.

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    Impact:

    • Subnarcotic halothane demonstrates a clear bronchodilating effect in COPD patients.
    • It offers a potential therapeutic option for acute severe bronchial obstruction when conventional treatments fail and contraindications are absent.