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[Enteral resorption kinetics in the aging process].

R Weiner, R Laue, F Dietze

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |March 1, 1986
    PubMed
    Summary
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    As people age, intestinal absorption slows but remains complete. Age-related absorption decline is linked to illness, not natural aging processes.

    Area of Science:

    • Gastroenterology
    • Physiology
    • Gerontology

    Context:

    • Aging leads to functional and morphological changes in the digestive system.
    • Intestinal absorption efficiency is a key factor in nutrient uptake and overall health.
    • Understanding age-related changes in absorption is crucial for geriatric care.

    Purpose:

    • To investigate the age-dependent changes in intestinal absorption using the D-xylose test.
    • To quantify the relationship between aging and the rate and extent of nutrient absorption.
    • To differentiate between age-related absorption decline and absorption issues due to illness.

    Summary:

    • The study evaluated intestinal absorption in individuals aged 3 to 96 years using a modified D-xylose absorption test.
    • Graphic-mathematical analysis of D-xylose blood kinetics revealed a decrease in absorption rapidity (k12) with increasing age.

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  • While absorption rate slows (prolonged time to peak concentration, tm), the small intestine remains capable of complete absorption in older adults.
  • Impact:

    • Findings suggest that age-related absorption disorders are primarily caused by co-existing morbidities rather than intrinsic aging (involution).
    • This research aids in distinguishing normal aging effects from pathological conditions affecting nutrient absorption in the elderly.
    • Highlights the importance of considering individual health status when assessing gastrointestinal function in older populations.