NT-proBNP and changes in cognition and global brain structure: The Rotterdam Study
Tian Xiao1, Isabelle F van der Velpen1,2, Wiro J Niessen1,2
1Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
European Journal of Neurology
|May 11, 2023
Summary
Higher levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) were linked to faster cognitive decline in older adults. However, this study found no association between NT-proBNP levels and changes in global brain structure.
Area of Science:
- Neurology
- Cardiology
- Gerontology
Background:
- N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a biomarker primarily used in heart failure diagnosis.
- Cognitive decline and changes in brain structure are significant concerns in aging populations.
Purpose of the Study:
- To investigate the relationship between NT-proBNP levels and cognitive function changes.
- To examine the association between NT-proBNP and global brain structure alterations.
Main Methods:
- Utilized data from the Rotterdam Study, including 9566 participants.
- Assessed NT-proBNP at baseline and conducted repeated cognitive tests over a median follow-up of 5.5 years.
- Performed repeated brain magnetic resonance imaging (MRI) on 2607 participants to evaluate brain structure.
Main Results:
- Higher NT-proBNP levels correlated with a faster decline in global cognitive function and Word-Fluency test scores.
- No significant association was found between NT-proBNP levels and deterioration in brain volumes, white matter integrity, or focal brain lesions.
Conclusions:
- Elevated NT-proBNP is associated with accelerated cognitive decline in older adults.
- NT-proBNP levels do not appear to be directly associated with measurable changes in global brain structure.
