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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Published on: December 11, 2016

Anticancer Drug Discovery By Structure-Based Repositioning Approach.

Dharti H Modh¹, Vithal M Kulkarni¹

¹Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be) University, Erandwane, Pune, 411038, Maharashtra, India.

Mini Reviews in Medicinal Chemistry

|May 11, 2023

Summary

This summary is machine-generated.

Drug repurposing screens existing medications for new anticancer uses. This review explores modifying antidiabetic, anti-HIV, and anti-inflammatory drugs for cancer therapy using structure-based drug design.

Keywords:

Anti-HIV Anti-diabetic Anti-inflammatory scaffolds/drugs Molecules.Repositioning Sulfonamides

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Area of Science:

Oncology
Pharmacology
Computational Chemistry

Background:

Cancer remains a leading global cause of death despite advances in science and medicine.
Developing novel anticancer drugs is costly and has uncertain success rates.
Drug discovery faces significant challenges, necessitating innovative approaches.

Approach:

Drug repurposing identifies new therapeutic indications for existing, approved drugs.
This involves screening known drugs for efficacy against different diseases.
Structure-based drug design (SBDD) is employed for molecular modification and computational screening.

Key Points:

Focuses on repurposing drugs used for diabetes, HIV infection, and inflammation as anticancer agents.
Reviews literature on molecular modeling and SBDD for drug repurposing.
Examines structural modifications and screening of repurposed drugs against cancer cell lines.

Conclusions:

Drug repurposing offers a promising strategy to accelerate the development of novel anticancer therapies.
Leveraging existing drug scaffolds can overcome traditional drug discovery hurdles.
This approach holds potential for identifying effective treatments for various cancers.