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The mTOR Signaling Pathway and mTOR Inhibitors in Cancer: Next-generation Inhibitors and Approaches
Murat Ihlamur1,2, Busra Akgul1, Yağmur Zengin3
1Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul, Turkey.
Current Molecular Medicine
|May 11, 2023
Summary
Targeting the mechanistic target of rapamycin (mTOR) pathway is crucial in cancer therapy. New nanoparticle-based strategies show promise in overcoming mTOR inhibitor resistance, offering a potential new treatment option.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- The mechanistic target of rapamycin (mTOR) pathway regulates cell growth, proliferation, and metabolism.
- Dysregulated mTOR signaling is implicated in various cancers.
- Current mTOR inhibitors face challenges due to resistance mechanisms.
Purpose of the Study:
- To review the role of mTOR in cancer.
- To discuss mTOR resistance mechanisms and current inhibitor efficacy.
- To explore novel nanoparticle-based mTOR inhibition strategies.
Main Methods:
- Literature review of mTOR functions, resistance, and inhibitors.
- Analysis of next-generation mTOR inhibitors.
- Evaluation of nanoparticle-based therapeutic approaches.
Main Results:
- mTOR pathway dysregulation drives cancer progression.
- Resistance mechanisms limit the effectiveness of existing mTOR inhibitors.
- Nanoparticle-mediated inhibition presents a promising therapeutic avenue.
Conclusions:
- Overcoming mTOR inhibitor resistance is critical for effective cancer treatment.
- Nanoparticle-based strategies offer a novel approach to target the mTOR pathway.
- Further research into nanoparticle applications may lead to improved cancer therapies.
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