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Does Exercise Attenuate Disease Progression in People With Parkinson's Disease? A Systematic Review With
Jiecheng A Li1, Marte B Loevaas1, Catherine Guan2
1Discipline of Movement Sciences, School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Neurorehabilitation and Neural Repair
|May 11, 2023
Summary
Exercise shows potential in slowing Parkinson's disease (PD) progression by improving motor scores and increasing BDNF levels. More research is needed to confirm these neuroplastic effects in PD patients.
Area of Science:
- Neuroscience
- Clinical Neurology
- Rehabilitation Medicine
Background:
- Parkinson's disease (PD) is a progressive neurodegenerative disorder.
- Exercise is recognized for its benefits in PD management, but its disease-modifying potential requires robust evidence.
- Neuroplastic effects of exercise are hypothesized to influence PD progression.
Conclusions:
- Limited evidence suggests exercise may attenuate markers of Parkinson's disease progression.
- Further large-scale RCTs are necessary to explore exercise type, dose, and PD stage effects.
- Future studies should standardize outcome reporting for PD progression indicators.
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