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Blood Biomarkers for Healthy Aging.
Ceereena Ubaida-Mohien1, Toshiko Tanaka1, Qu Tian1
1Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Discovering new blood biomarkers, informed by geroscience and advanced -omic technologies, is crucial for personalized health and healthy aging, moving beyond traditional disease markers.
Area of Science:
- Biomarker discovery
- Geroscience
- Translational medicine
Background:
- Blood biomarkers are vital for medical diagnosis and research but have seen limited innovation in routine practice for decades.
- Novel biomarker discovery is essential for improving risk stratification, disease monitoring, and treatment effectiveness.
- Geroscience integrates aging research with clinical applications, shifting focus towards health promotion and healthy aging.
Purpose of the Study:
- To review the integration of biomarker discovery with geroscience.
- To highlight the role of new -omic technologies in developing advanced blood biomarkers.
- To discuss the paradigm shift towards promoting health and healthy aging.
Main Methods:
- Review of current literature on biomarker discovery and geroscience.
- Analysis of the impact of -omic technologies (epigenetic, proteomic, metabolomic, lipidomic) on biomarker development.
- Integration of medical gerontology frameworks with high-technology research.
Main Results:
- Limited evolution of routine blood biomarkers despite technological advancements.
- -Omic technologies are yielding novel blood markers correlating with health status.
- Geroscience provides a framework for translating aging research into clinical practice.
Conclusions:
- The convergence of geroscience and advanced -omic technologies is revolutionizing blood biomarker discovery.
- These novel biomarkers are key to advancing personalized medicine and promoting healthy aging.
- A paradigm shift is occurring from disease-centric approaches to healthspan optimization.
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