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Updated: Jul 30, 2025
Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
Published on: November 30, 2018
Study on Calceolarioside A Anti-Aβ25-35 -Induced Damage in SH-SY5Y cells by Atomic Force Microscopy
Yujuan Chen1,2,3, Kaige Qu2,3, Ying Wang2,3
1School of Life Sciences, Changchun University of Science and Technology, Changchun, 130022, China.
Abstract:
Calceolarioside A is a phenylethyl glycoside compound, originally isolated from the bark of Fraxinus mandshurica Rupr. In this work, the protective effect of Calceolarioside A on beta Amyloid protein induced toxicity in SH-SY5Y cells was studied. DPPH experiment, MTT assay, SEM, Atomic force microscopy and Colony formation were used to study the activity of Calceolarioside A. The results in this article show that the survival rate of the cells with Calceolarioside A (20-40 mg/mL) was significantly higher than that of the model cells without Calceolarioside A. Calceolarioside A could protect SH-SY5Y cells by improving some parameters in cells, such as the cell height, Young's modulus, adhesion and branch. In summary, Calceolarioside A can reduce Aβ25-35 -induced damage in SH-SY5Y cells. It can be a potential medicine to treatment with AD.
