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ANALYSIS OF CLINICAL AND LABORATORY PARAMETERS CHILDREN WITH DIABETES MELLIUS TYPE 1 USING DIFFERENT TYPES OF INSULIN

G Ahmadov1

  • 1II Department of Children's Diseases, Azerbaijan Medical University, Azerbaijan.

Georgian Medical News
|May 11, 2023
PubMed

Insights

Insulin Glargine use in children resulted in lower glycohemoglobin and glucose levels compared to Insulin human (Insulatard). Insulin Detemir showed a positive correlation with body mass, unlike Insulin Glargine.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Disorders

Background:

  • Type 1 diabetes management in children requires careful insulin selection.
  • Different insulin analogs possess unique pharmacokinetic and pharmacodynamic profiles.
  • Understanding the comparative efficacy of various insulin types is crucial for optimizing glycemic control.

Purpose of the Study:

  • To compare clinical and laboratory parameters in children with diabetes using different insulin regimens.
  • To evaluate the impact of Insulin human (Insulatard), Insulin Glargine, and Insulin Detemir on glycemic control and lipid profiles.
  • To investigate correlations between insulin dosage, body weight, height, and metabolic markers.

Main Methods:

  • Comparative analysis of 49 children with diabetes, divided into three groups based on insulin type: Insulin human (Insulatard), Insulin Glargine, and Insulin Detemir.
  • All patients received short-acting insulin Aspart (Glargine/Detemir groups) or Human insulin (rDNA, Actrapid) (Insulatard group).
  • Laboratory determination of blood glucose, glycohemoglobin, and cholesterol, with statistical analysis at p<0.05.

Main Results:

  • Insulin Glargine users exhibited significantly lower mean glycohemoglobin and glucose levels compared to Insulin human (Insulatard) users (p<0.05).
  • A positive correlation was observed between Insulin human (Insulatard) and regular insulin doses with body weight and height.
  • Insulin Detemir showed a positive correlation with body mass, while Insulin Glargine did not correlate with body mass or height. A negative correlation was found between Insulin Glargine dose and glycohemoglobin, glucose, and cholesterol.

Conclusions:

  • Insulin Glargine demonstrates superior efficacy in reducing glycohemoglobin and glucose levels in pediatric patients compared to Insulin human (Insulatard).
  • Insulin Detemir's dosage correlates with body mass, suggesting potential dose adjustments based on weight.
  • Insulin Glargine shows a dose-dependent inverse relationship with key metabolic markers, indicating its effectiveness in glycemic and lipid management.

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