Predicting Plant miRNA-lncRNA Interactions via a Deep Learning Method

In recent years, due to the contribution to elucidating the functional mechanisms of miRNAs and lncRNAs, the research on miRNA-lncRNA interaction prediction has increased exponentially. However, the prediction research is challenging in bioinformatics domain. It is expensive and time-consuming to verify the interactions by biological experiments. The existing prediction models have some limitations, such as the need to manually extract features, the potential loss of features from pre-treatment approaches, long-distance dependency to be solved, and so on. Additionally, most of the current models prefer to the animal data. However, the establishment of an efficient and accurate plant miRNA-lncRNA interaction prediction model is necessary. In this work, a new deep learning model called PmlIPM is presented to infer plant miRNA-lncRNA associations. PmlIPM is a four-step framework including Input Embedding, Positional Encoding, Multi-Head Attention and Max Pooling. PmlIPM accepts separately input of miRNA and lncRNA to extract sequence features, avoiding information loss caused by direct splicing the two sequences as model inputs. The attention mechanisms give the model the ability to capture long distance features. PmlIPM is compared with the existing models on 2 benchmark datasets. The results show that our model performs better than other methods and obtains AUC scores of 0.8412, 0.8587, 0.9666 and 0.9225 in the four independent test sets of Arabidopsis lyrata (A.ly), Solanum lycopersicum (S.ly), Brachypodium distachyon (B.di) and Solanum tuberosum (S.tu), respectively.