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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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A Post-Pandemic Enigma: The Cardiovascular Impact of Post-Acute Sequelae of SARS-CoV-2

Tamanna K Singh1,2,3, David A Zidar3,4, Keith McCrae5,2,3

  • 1Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH (TKS, MC, SJC).

Circulation Research
|May 11, 2023
PubMed

Insights

Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, or long COVID, affects one-third of survivors. This review explores its cardiovascular impact and potential treatments.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • The COVID-19 pandemic has caused unprecedented global mortality and morbidity.
  • Post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID, is increasingly recognized as a significant public health challenge.
  • A substantial proportion of SARS-CoV-2 survivors experience persistent symptoms, many with cardiovascular implications.

Purpose of the Study:

  • To review the suspected pathophysiology of PASC.
  • To examine the influence of PASC on the cardiovascular system.
  • To discuss potential therapeutic strategies for cardiovascular manifestations of PASC.

Main Methods:

  • This review synthesizes current literature on PASC and cardiovascular sequelae.
  • It examines proposed mechanisms underlying long COVID's cardiovascular effects.
  • It explores emerging and established treatment approaches.

Main Results:

  • PASC can manifest with a range of cardiovascular symptoms, including arrhythmias, myocarditis, and endothelial dysfunction.
  • The pathophysiology is multifactorial, potentially involving persistent viral reservoirs, autoimmune responses, and inflammation.
  • Long COVID poses a significant burden on cardiovascular health in a large number of survivors.

Conclusions:

  • Understanding the cardiovascular impact of PASC is crucial for effective patient management.
  • Further research into the pathophysiology of PASC is needed to develop targeted treatments.
  • Comprehensive strategies are required to address the long-term cardiovascular consequences of SARS-CoV-2 infection.

Keywords:
COVID-19SARS-CoV-2infectionspandemicssurvivors

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