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Pain tolerance after stroke: The Tromsø study.

Tonje Anita Melum1,2,3, Anders P Årnes3, Hein Stigum4

  • 1Department of Neurology, University Hospital of Northern Norway, Tromsø, Norway.

European Journal of Pain (London, England)
|May 11, 2023
PubMed
Summary

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Exploring hemodynamic measurements from the Tromsø Study for prediction of cardiovascular disease using traditional statistical models and machine learning approaches.

Scientific reports·2026
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Urinary orosomucoid and the risk of cardiovascular events and all-cause mortality in the general population. The Tromsø Study 2007-2021.

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Psychometric evaluation of the Level of Personality Functioning Scale - Brief Form 2.0 in adults with chronic pain.

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Incidence of proximal humerus fracture among older adults in Oslo, Norway varies by country background, marital status, and season.

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Survival after wake-up stroke and unknown-onset stroke-a nationwide observational study from the Norwegian Stroke Registry.

European stroke journal·2026

Stroke survivors exhibit reduced cold pain tolerance compared to individuals without a stroke history. This finding holds true for both those with and without chronic pain, suggesting altered pain processing post-stroke.

Area of Science:

  • Neurology
  • Pain Medicine
  • Public Health

Background:

  • Stroke can impact the brain's pain processing network.
  • Understanding pain modulation after stroke is crucial.

Purpose of the Study:

  • To compare cold pain tolerance in stroke survivors versus stroke-free individuals.
  • To investigate pain tolerance in stroke survivors with and without chronic pain.

Main Methods:

  • Utilized data from the Tromsø Study (6th and 7th waves).
  • Employed the cold pressor test (CPT) to assess pain tolerance.
  • Analyzed data using Cox regression, adjusting for cardiovascular risk factors.

Main Results:

  • 21,837 participants included; 311 had a history of stroke.

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  • Stroke survivors showed a 28% increased hazard of hand withdrawal during CPT (HR 1.28).
  • This association was consistent across participants with and without chronic pain.
  • Conclusions:

    • Stroke survivors have diminished cold pain tolerance.
    • This reduced tolerance is evident regardless of chronic pain status.
    • Healthcare professionals should be more aware of pain in stroke patients.