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Updated: Jul 30, 2025

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
Published on: September 6, 2015
Calcium regulation by SERC-A before and during Alzheimer disease
Alamira Farah Alwiraikat-Flores1, Pablo Octavio-Aguilar2
1Laboratorio de Genética, Área Académica de Biología, Universidad Autónoma del Estado de Hidalgo, Hidalgo, México. biomedica@ins.gov.co.
Abstract:
There are many factors involved in the incidence of Alzheimer’s disease that, in combination, impede or hinder normal neuronal functions. Little is currently known about calcium regulation before and during the disease. Internal instability of calcium levels is associated with increased vascular risk, a prevalent condition in a high number of individuals already compromised by Alzheimer’s disease. This review provides a reevaluation of the molecular mechanism of the sarcoendoplasmic reticulum calcium ATPase (SERC-A) in the disease and discusses salient aspects of voltage-gated calcium channel function; in these way new alternatives could be open for its treatment. These regulation mechanisms are clinically relevant since the irregular functions of SERC+A has been implicated in pathologies of brain function.
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