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Updated: Jul 30, 2025

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
Published on: December 28, 2010
20 years of the default mode network: A review and synthesis
1Department of Psychiatry & Behavioral Sciences and Department of Neurology & Neurological Sciences, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Abstract:
The discovery of the default mode network (DMN) has revolutionized our understanding of the workings of the human brain. Here, I review developments that led to the discovery of the DMN, offer a personal reflection, and consider how our ideas of DMN function have evolved over the past two decades. I summarize literature examining the role of the DMN in self-reference, social cognition, episodic and autobiographical memory, language and semantic memory, and mind wandering. I identify unifying themes and propose new perspectives on the DMN's role in human cognition. I argue that the DMN integrates and broadcasts memory, language, and semantic representations to create a coherent "internal narrative" reflecting our individual experiences. This narrative is central to the construction of a sense of self, shapes how we perceive ourselves and interact with others, may have ontogenetic origins in self-directed speech during childhood, and forms a vital component of human consciousness.
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