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Sex-linked pattern of collaterals in iliac artery occlusive disease
Insights
Iliac artery occlusion can lead to collateral circulation. Thoracic artery collaterals, rare in patients with iliac artery occlusion, show a significant male preponderance.
Area of Science:
- Vascular Surgery
- Angiology
- Radiology
Background:
- Iliac artery occlusion is a significant vascular condition.
- Collateral circulation is crucial for blood supply restoration.
- Understanding patterns of collateralization is key for treatment.
Purpose of the Study:
- To investigate the origin and characteristics of collateral circulation in patients with aorto-femoral disease.
- To determine if there are sex-linked differences in collateral pathway development.
Main Methods:
- Aorto-femoral angiography was performed on 839 patients.
- Data on iliac artery occlusion and collateral supply origin were analyzed.
- Chi-squared test was used to assess statistical significance.
Main Results:
- 139 patients had common or external iliac artery occlusion.
- Pelvic or lumbar/intercostal arteries were collaterals in 786 patients.
- Thoracic arteries served as collaterals in 53 patients, predominantly males (46 males vs. 7 females).
Conclusions:
- Thoracic artery collateralization in iliac artery occlusion is uncommon.
- A significant male preponderance exists for thoracic collateral development.
- This suggests a sex-linked factor influencing collateral pathway selection.
Abstract:
Aorto-femoral angiography carried out in 839 patients revealed that 139 males and females had uni- or bilateral occlusion of the common or external iliac arteries. Pelvic or lumbar/intercostal arteries served as collaterals in 786 patients. In the remaining 53 patients the collateral blood supply originated from the thoracic arteries. Among the 53 patients, only 7 were females. A chi 2-test revealed the difference to be significant (p less than 0.0005), indicating a sex-linked difference, a male preponderance, in the development of collateral circulation of thoracic origin.