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Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
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Linking leptin in GCF with tooth movement among Indians.

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  • 1Department of Dentistry, Fakir Mohan Medical College, Balasore, Odisha 756019, India.

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Summary

Leptin in gingival crevicular fluid (GCF) shows a biphasic change during orthodontic tooth movement, peaking at 24 hours. This GCF leptin concentration is significantly associated with the rate of tooth movement.

Keywords:
GCFleptin concentrationorthodontic forcetooth movement

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Area of Science:

  • Biochemistry
  • Orthodontics
  • Periodontology

Background:

  • Leptin, a hormone involved in bone metabolism, may play a role in orthodontic tooth movement.
  • Gingival crevicular fluid (GCF) is a transudate reflecting the inflammatory and metabolic status of the periodontium.

Purpose of the Study:

  • To investigate the association between orthodontic tooth movement and leptin concentration in GCF.
  • To analyze the dynamic changes in GCF leptin levels during the initial phase of orthodontic force application.

Main Methods:

  • GCF samples were collected from 30 orthodontic patients at five time points: baseline, 1 hour, 24 hours, 7 days, and 1 month post-force application.
  • Leptin concentration in GCF was measured using standardized methods.
  • Tooth movement was quantified using dental casts.
  • Statistical analysis included one-way ANOVA with Bonferroni correction and Pearson's correlation test.

Main Results:

  • GCF leptin concentration exhibited a biphasic pattern, increasing from baseline to a peak at 24 hours, then decreasing at 7 days, and rising again at 1 month.
  • A statistically significant correlation (r=0.625) was found between the average GCF leptin concentration and the degree of tooth movement.
  • The observed changes in GCF leptin levels were statistically significant (P < 0.05).

Conclusions:

  • GCF leptin concentration undergoes significant biphasic changes in response to orthodontic force.
  • There is a significant positive association between GCF leptin levels and the rate of orthodontic tooth movement.