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Published on: February 27, 2014
Association between vitamin D level and pediatric inflammatory bowel disease: A systematic review and meta-analysis
Yan-Hong Sun1, Dan-Dan Tian1, Jian-Ming Zhou1
1Department of "A", Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Insights
This study found no direct link between vitamin D levels and pediatric inflammatory bowel disease (IBD). However, vitamin D supplementation may help reduce disease activity in children with IBD.
Area of Science:
- Pediatric Gastroenterology
- Nutritional Immunology
- Inflammatory Bowel Disease Research
Background:
- The relationship between vitamin D and pediatric inflammatory bowel disease (IBD) incidence remains unclear.
- Previous research suggests a potential link, necessitating further investigation.
Purpose of the Study:
- To systematically evaluate the association between vitamin D levels and pediatric IBD.
- To determine the impact of vitamin D supplementation on disease activity in pediatric IBD patients.
Main Methods:
- A comprehensive literature search was conducted across major scientific databases (PubMed, EMBASE, Medline, Web of Science, Google Scholar) up to January 2023.
- Data from sixteen relevant studies were extracted and analyzed using meta-analysis techniques.
Main Results:
- No significant difference in average vitamin D levels was observed between pediatric IBD patients and healthy controls.
- Vitamin D supplementation was associated with a significant reduction in C-reactive protein (CRP) levels (SMD = 2.65).
- Patients with IBD in remission showed a trend towards improvement after vitamin D supplementation (OR = 0.72).
Conclusions:
- Current evidence does not support a direct relationship between vitamin D levels and the incidence of pediatric IBD.
- Vitamin D supplementation appears to be beneficial in improving disease activity and reducing inflammatory markers in pediatric IBD.
- Further prospective studies are required to definitively establish the role of vitamin D in pediatric IBD.
Background:
Previous studies have reported that the incidence of pediatric inflammatory bowel disease (IBD) is related to vitamin D, but it is still unclear. This study intends to calculate the relationship between pediatric IBD and vitamin D.
Methods:
A comprehensive literature search from inception to January 2023 was performed in the PubMed, EMBASE, Medline, Web of Science, and Google Scholar databases. Relevant data were extracted as required and used for subsequent calculations.
Results:
Sixteen papers were included, and there was no significant difference between the average vitamin D level in IBD patients and healthy controls. In addition, the overall pooled results showed that C-reactive protein (CRP) was 2.65 higher before vitamin D supplementation than after supplementation [SMD = 2.65, 95% CI = (2.26, 3.04)]. Moreover, patients with IBD in remission were 0.72 higher before vitamin D supplementation than after supplementation [OR = 0.72, 95% CI = (0.52, 1.00)].
Conclusion:
This study suggested that there was no obvious relationship between pediatric IBD and vitamin D, while vitamin D supplementation can improve disease activity. Therefore, follow-up still needs many prospective studies to confirm the relationship between pediatric IBD and vitamin D.
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