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Myotonic dystrophy treated with selenium and vitamin E.

G Orndahl, U Selldén, S Hallin

    Acta Medica Scandinavica
    |January 1, 1986
    PubMed
    Summary

    Selenium and vitamin E supplementation improved multiple symptoms in five patients with myotonic dystrophy. Early-stage patients showed faster, more significant improvements in strength and function, with no adverse effects observed.

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    Area of Science:

    • Neurology
    • Nutritional Science

    Background:

    • Myotonic dystrophy is a progressive genetic disorder affecting muscle function.
    • Previous case reports suggested potential benefits of selenium and vitamin E therapy.

    Purpose of the Study:

    • To evaluate the efficacy of selenium and vitamin E in a larger cohort of myotonic dystrophy patients.
    • To assess objective and subjective improvements in muscle function and disease progression.

    Main Methods:

    • Five patients with myotonic dystrophy received daily supplementation of 4 mg sodium selenite (Na2SeO3) and 600 mg vitamin E.
    • Clinical assessments included grip strength (vigorimeter), gait analysis, functional mobility tests, and electromyography (EMG).
    • Serum selenium levels were monitored throughout the study.

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    Main Results:

    • All five patients demonstrated subjective and objective improvements in at least two functional areas.
    • Significant improvements were noted in grip strength, gait normalization, and the ability to perform specific physical tasks (e.g., sitting to standing, rising from floor).
    • EMG showed a reduction in myotonic discharges, and early-stage patients exhibited more rapid and pronounced recovery.

    Conclusions:

    • Combined selenium and vitamin E supplementation appears to be a safe and effective treatment for myotonic dystrophy.
    • The therapy can lead to measurable improvements in muscle strength, function, and electrophysiological parameters.
    • Early intervention may yield better therapeutic outcomes in myotonic dystrophy patients.