Adjunctive Dietary Therapy Is Associated With Improved Gastrointestinal Symptoms in Steroid-Refractory

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Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
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Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

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Tanyaporn Kaenkumchorn1, David L Suskind1, Dale Lee1

  • 1From the Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA.

JPGN Reports
|May 11, 2023
PubMed

Acute gastrointestinal graft-versus-host disease (GI GVHD) is a complication after hematopoietic stem cell transplant with high morbidity and mortality. In particular, steroid-refractory GI GVHD can be difficult to treat. Recent investigations have revealed that patients after transplant can experience intestinal dysbiosis contributing to the progression of GVHD. Modulation of the gut microbiome through dietary intake could potentially improve the intestinal dysbiosis in GI GVHD. In this case series, we present 3 patients where dietary therapy was used in conjunction with immunosuppression to achieve clinical remission of GI GVHD.

Keywords:
dietexclusive enteral nutritiongastrointestinalgraft-versus-host diseasepediatricsspecific carbohydrate diet

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