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The Risk of Colonic Strictures with Colitis Following Hemolytic Uremic Syndrome: A Case Report of a Toddler

Yasemin Cagil1, Serena Tan2, Michael Fadell3

  • 1From the Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Palo Alto, CA.

JPGN Reports
|May 11, 2023
PubMed

Insights

Hemolytic uremic syndrome (HUS) gastrointestinal complications are rare in children. Enterohemorrhagic Escherichia coli (EHEC) can cause chronic colitis and strictures, highlighting long-term HUS effects.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Nephrology

Background:

  • Hemolytic uremic syndrome (HUS) is a serious condition with rare gastrointestinal (GI) manifestations in children.
  • Enterohemorrhagic Escherichia coli (EHEC) is a known pathogen associated with post-diarrheal HUS.
  • Understanding the GI impact of HUS is crucial for pediatric patient management.

Observation:

  • A previously healthy 3-year-old boy presented with bloody diarrhea.
  • The patient tested positive for EHEC infection.
  • The child subsequently developed severe gastrointestinal complications characteristic of HUS.

Findings:

  • The pediatric patient experienced chronic colitis and strictures as a result of HUS.
  • This case confirms the potential for significant long-term GI sequelae following EHEC-induced HUS.
  • Gastrointestinal complications, though infrequent, can profoundly affect the disease course.

Implications:

  • This case underscores the importance of recognizing and managing rare GI complications of HUS in pediatric populations.
  • Early identification and intervention for EHEC infection may mitigate severe GI outcomes.
  • Further research into the pathogenesis and long-term effects of HUS-related GI issues is warranted.

Keywords:
EHECHUScolitishemolytic uremic syndromeinfectious diarrheastrictures

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