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Chronic corticosterone improves perseverative behavior in mice during sequential reversal learning.

Anna U Odland1, Rune Sandahl1, Jesper T Andreasen1

  • 1Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Behavioural Brain Research
|May 11, 2023
PubMed
Summary

Stress from corticosterone (CORT) improved cognitive flexibility in mice by reducing perseverative behaviors during reversal learning. This suggests stress may enhance adaptation to changing reward contingencies.

Keywords:
Cognitive flexibilityCorticosteroneExtinction learningMouse behaviorReversal learningStress

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Psychopharmacology

Background:

  • Stressful events can trigger psychiatric disorders or promote adaptive behavioral changes.
  • The impact of stress on cognitive flexibility is complex and yields varied outcomes in humans and animals.

Purpose of the Study:

  • To investigate the effects of stress on cognitive flexibility in a mouse model.
  • To understand how stress influences behavioral adaptation to changing environments.

Main Methods:

  • Female mice received corticosterone (CORT) in drinking water for two weeks as a model of stress.
  • Cognitive flexibility was assessed using a touchscreen-based sequential reversal learning test.
  • Anxiety-like behavior and locomotor activity were measured in supplementary tests.

Main Results:

  • CORT administration reduced perseveration during reversal learning without affecting new learning acquisition.
  • CORT increased anxiety-like behavior and repetitive digging but decreased locomotor activity.
  • No significant effect of CORT was observed on spontaneous alternation behavior.

Conclusions:

  • Corticosterone improved cognitive flexibility by enhancing the extinction of non-rewarded responses.
  • Stress may increase sensitivity to negative feedback, facilitating adaptation to unrewarded stimuli.
  • Further research is needed to confirm these findings in larger studies.