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Narrowing the translational research gap by aligning replication concepts in basic and clinical neuroscience
Alan S Lewis1, William P Nobis2
1Departments of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Brain Institute and Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA.
Replication in neuroscience differs between basic and clinical studies. Aligning these concepts can accelerate translating fundamental nervous system discoveries into new treatments for brain disorders.
Area of Science:
- Neuroscience
- Translational Research
- Scientific Validity
Background:
- Replicability and reproducibility are crucial for scientific research validity.
- Replication processes differ between fundamental neuroscience and clinical neuroscience involving patients.
- This discrepancy can hinder the translation of basic findings into clinical applications.
Purpose of the Study:
- To discuss aligning the concept of replication across the translational spectrum in neuroscience.
- To enhance the translation of basic neuroscience findings into treatments for neurological and psychiatric disorders.
Main Methods:
- Conceptual analysis and discussion of replication principles.
- Comparison of replication elements in fundamental versus clinical neuroscience.
- Exploration of translational challenges in neuroscience research.
Main Results:
- Current replication practices in fundamental and clinical neuroscience are not fully congruent.
- A gap exists in the seamless application of replication across basic and patient-involved research.
- Potential strategies for aligning replication concepts are proposed.
Conclusions:
- Aligning replication concepts across basic and clinical neuroscience is essential.
- Improved alignment can accelerate the development of novel treatments for psychiatric and neurological disorders.
- Enhancing translational efficiency in neuroscience research is a key outcome.
