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An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System
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Thalamocortical coherence predicts persistent postconcussive symptoms.

Yi-Tien Li1, Duen-Pang Kuo2, Philip Tseng3

  • 1Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan; Neuroscience Research Center, Taipei Medical University, Taipei 11031, Taiwan.

Progress in Neurobiology
|May 11, 2023
PubMed
Summary
This summary is machine-generated.

Persistent post-concussive symptoms (PCS) may stem from thalamic reticular nucleus (TRN) injury, leading to disrupted thalamocortical coherence. Functional MRI coherence measures show promise as early biomarkers for predicting long-term PCS outcomes.

Keywords:
Coherence biomarkersConcussionMachine learningPersistent postconcussive symptomsThalamic reticular nucleusThalamocortical coherence

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Pathophysiology

Background:

  • The underlying mechanisms of persistent post-concussive symptoms (PCS) after concussion are not fully understood.
  • Thalamic damage is implicated in PCS, but specific biomarkers triggering its persistence remain elusive.

Purpose of the Study:

  • To identify early biomarkers for persistent PCS using longitudinal neuroimaging and behavioral data from patients and rodents.
  • To investigate the role of thalamic damage and thalamocortical coherence in the development of prolonged PCS.

Main Methods:

  • Longitudinal diffusion tensor imaging (DTI) and resting-state functional MRI (rs-fMRI) were used in patients and rodents.
  • Quantitative thalamocortical coherence was derived from rs-fMRI to assess brain function and predict outcomes.
  • Rodent histological staining (immunohistochemistry) of the thalamic reticular nucleus (TRN) was performed.

Main Results:

  • Patients with prolonged PCS exhibited abnormal DTI indices in peri-thalamic regions.
  • Both patients and rodents with persistent PCS showed enhanced thalamocortical coherence, disrupting brain multifunctionality.
  • In rodents, DTI abnormalities in the TRN correlated with enhanced thalamocortical coherence, and these coherence measures predicted long-term PCS in a separate patient cohort.

Conclusions:

  • Persistent TRN injury may initiate a cascade leading to disrupted thalamocortical coherence and prolonged PCS.
  • Functional MRI-based thalamocortical coherence measures serve as reliable surrogate biomarkers for early prediction of long-term PCS.