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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

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Long COVID Syndrome: A Case-Control Study.

Rachel-Anne Xuereb1, Marica Borg2, Kevin Vella2

  • 1Mater Dei Hospital, Msida, Malta; University of Malta Medical School, Msida.

The American Journal of Medicine
|May 11, 2023
PubMed
Summary
This summary is machine-generated.

Post-COVID-19 patients experience persistent symptoms and ongoing inflammation for months after infection. This study highlights medium-term cardiovascular sequelae and their association with inflammation markers like high-sensitivity C-reactive protein (hsCRP).

Keywords:
Health-related quality of lifeHigh-sensitivity C-reactive proteinLong COVIDTroponin

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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Acute COVID-19 (coronavirus disease 2019) is linked to cardiovascular complications.
  • Long-term cardiovascular effects post-COVID-19 remain largely unknown.
  • Investigating medium-term sequelae is crucial for patient management.

Purpose of the Study:

  • Assess symptomatology and health-related quality of life (HRQoL) at 6 months post-COVID-19.
  • Determine if COVID-19 history and persistent shortness of breath correlate with inflammation, endothelial dysfunction, and cardiac injury.
  • Evaluate ongoing systemic inflammation markers in post-COVID-19 patients.

Main Methods:

  • Case-control study comparing 174 COVID-19 survivors with 75 age- and gender-matched controls.
  • Interviews to assess symptoms and HRQoL using the Short Form Survey-36.
  • Biochemical tests including high-sensitivity C-reactive protein (hsCRP), troponin I, and hemoglobin levels.

Main Results:

  • COVID-19 survivors reported increased shortness of breath, fatigue, arthralgia, and altered taste/smell compared to controls.
  • Cases showed significantly higher hsCRP levels, positively correlated with time post-infection.
  • Persistent shortness of breath was associated with age, female gender, white cell count, troponin I, and lower hemoglobin.

Conclusions:

  • Post-COVID-19 patients exhibit persistent symptoms at medium-term follow-up.
  • Elevated hsCRP and its association with time indicate ongoing systemic inflammation for months.
  • Findings suggest potential for medium-term cardiovascular sequelae requiring further investigation.