Related Experiment Video
Updated: Jul 30, 2025
08:50
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
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[Nephron sparing in the management of localized solid renal mass]
Sylvain Bodard1, Charles Dariane2, Jean-Emmanuel Bibault3
1AP-HP, hôpital Necker-Enfants-Malades, service d'imagerie adulte, 75015 Paris, France; Université de Paris-Cité, 75006 Paris, France; Sorbonne université, laboratoire d'imagerie biomédicale, CNRS, Inserm, Paris, France; Groupe de recherche interdisciplinaire francophone en onco-néphrologie (GRIFON), Paris, France.
Bulletin Du Cancer
|May 11, 2023
Summary
Treatment for malignant renal tumors prioritizes preserving kidney function, especially when it
Area of Science:
- Nephrology
- Urology
- Oncology
Context:
- Malignant renal tumors impact kidney function in 50% of diagnoses.
- Treatment decisions are complex, involving renal function, CKD risk, dialysis needs, and survival.
- Tumor characteristics (size, location, number, hereditary factors) influence management.
Purpose:
- To outline a strategic approach for managing malignant renal tumors.
- To emphasize the importance of renal function preservation in treatment planning.
- To guide the selection of appropriate interventions based on patient and tumor factors.
Summary:
- Renal-sparing management is preferred for small malignant renal masses (cT1a) over total nephrectomy.
- Treatment options include partial nephrectomy, lumpectomy, and percutaneous thermo-ablation (radiofrequency, microwave, cryotherapy).
- For patients with limited life expectancy, imaging-based surveillance may be suitable, with treatment initiated upon local progression.
Impact:
- Optimized patient management through multidisciplinary collaboration (urologist, radiologist, nephrologist, radiotherapist).
- Improved outcomes for patients with malignant renal tumors, particularly those with pre-existing renal failure.
- Reduced incidence of chronic kidney disease and dialysis dependency through tailored treatment strategies.
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