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Updated: Aug 19, 2026

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells
Published on: July 16, 2011
Regulation of differentiation in transformed erythroid cells
Abstract:
Murine erythroleukemia cells provide a model for the study of erythropoietic differentiation uncoupled from the normal requirement for erythropoietin for cell proliferation. Evidence is presented which suggests that differentiation-inducing chemicals may have a number of cellular sites of action, including effects at the plasma membrane and on chromatin, but a common pathway may include a transient delay of the cell cycle in G1, alterations in chromatin structure, and the expression of a complex pattern of gene transcription responsible for the program of differentiation.
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