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Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae.

Yumei Yan1,2, Xinxin Wei3, Bin Qiu4

  • 1Department of Pharmacy, Baotou Medical College, Baotou, 014040, China.

Scientific Reports
|May 11, 2023
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Summary
This summary is machine-generated.

This study analyzes the medicinal plants of Lithospermeae, integrating phytochemistry, pharmacology, and traditional uses. Findings offer a scientific basis for Lithospermeae research and resource development.

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Area of Science:

  • Botany
  • Pharmacology
  • Phylogenetics

Background:

  • Lithospermeae Dumort. is a tribe of perennial herbs with approximately 470 species in 26 genera, found in temperate and tropical regions.
  • Understanding the medicinal value, phytochemistry, and pharmacology of Lithospermeae is crucial for resource protection and development.

Purpose of the Study:

  • To analyze the phytochemistry, pharmacology, and traditional uses of medicinal Lithospermeae species.
  • To explore the genetic origins and pharmaphylogeny of Lithospermeae using molecular and spatial analyses.
  • To provide scientific guidance for Lithospermeae research and the development of its medicinal resources.

Main Methods:

  • Phylogenetic analysis using internal transcribed spacer sequences.
  • Spatial analysis and species distribution modeling for distribution patterns.
  • Network pharmacology to predict targets and pathways for pharmacological effects.

Main Results:

  • First-time compilation and analysis of chemical composition, traditional efficacy, and modern pharmacological activity of Lithospermeae.
  • Preliminary discussion on the pharmaphylogeny of Lithospermeae, integrating geographical distribution, molecular phylogeny, and network pharmacology.
  • Exploration of the relationship between regional medicinal plant industry development and biodiversity protection.

Conclusions:

  • The study provides a scientific foundation for basic research on Lithospermeae.
  • Findings offer theoretical guidance for studying medicinal plant phylogeny and developing Lithospermeae resources.
  • Highlights the link between economic development of medicinal plants and biodiversity conservation.