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Microbial tolerance engineering for boosting lactic acid production from lignocellulose.

Wenwen Shan1,2, Yongli Yan1,2, Yongda Li3

  • 1Department of Biophysics, Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou, 730000, People's Republic of China.

Biotechnology for Biofuels and Bioproducts
|May 11, 2023
PubMed
Summary

Microbial tolerance engineering enhances lactic acid production from lignocellulosic biomass by improving microbial resistance to inhibitors. This review guides the development of robust microbial cell factories for cost-effective cellulosic lactic acid production.

Keywords:
InhibitorLactic acidPretreatmentTolerance modification

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Area of Science:

  • Biotechnology and Bioengineering
  • Industrial Microbiology
  • Metabolic Engineering

Background:

  • Lignocellulosic biomass offers a sustainable, non-food feedstock for lactic acid production, reducing food supply conflicts.
  • Pretreatment processes generate inhibitors that hinder microbial growth, reduce feedstock conversion, and increase production costs.
  • Developing microbial tolerance to these inhibitors is crucial for efficient cellulosic lactic acid production.

Purpose of the Study:

  • To review recent advancements in microbial tolerance engineering for lactic acid production using lignocellulosic hydrolysates.
  • To highlight strategies for developing robust microbial cell factories capable of withstanding inhibitors.
  • To provide a guide for economically viable cellulosic lactic acid production.

Main Methods:

  • Review of literature on microbial tolerance engineering strategies.
  • Analysis of inhibitor tolerance mechanisms in microbes.
  • Discussion of breeding tools and novel approaches for enhancing microbial robustness.
  • Examination of applications in cellulosic lactic acid production.

Main Results:

  • Significant progress has been made in engineering microbes for enhanced tolerance to lignocellulose-derived inhibitors.
  • Engineered microbial cell factories demonstrate improved performance in converting pretreated lignocellulose hydrolysates.
  • Integration of tolerance engineering with other breeding tools can further optimize production efficiency.

Conclusions:

  • Microbial tolerance engineering is a key strategy for overcoming inhibitor challenges in cellulosic lactic acid production.
  • Development of robust microbial strains is essential for cost-effective and sustainable lactic acid manufacturing.
  • This review provides a framework for future research and development in the field.