Related Experiment Video
Updated: Jul 30, 2025
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Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
Published on: August 2, 2021
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Behavioral activation for depression in patients with advanced cancer: study protocol for a multicenter randomized
Takatoshi Hirayama1, Yuko Ogawa2, Asao Ogawa3
1Department of Psycho-Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan. thirayam@ncc.go.jp.
BMC Cancer
|May 11, 2023
Summary
Behavioral activation (BA) effectively treats depression in advanced cancer patients. This study provides evidence for BA as a feasible intervention to improve mood and life purpose in this population.
Area of Science:
- Psychiatry
- Oncology
- Clinical Psychology
Background:
- Behavioral activation (BA) is effective for depression, but its efficacy in advanced cancer patients is not established.
- This study investigates the effectiveness of a BA program for depression in patients with advanced cancer.
Purpose of the Study:
- To examine the effectiveness of a BA program on depression in patients with advanced cancer.
- To provide evidence for BA as an acceptable and feasible intervention for depression in this population.
Main Methods:
- A multicenter randomized controlled trial with a wait-list control group involving 38 advanced cancer patients with depression.
- The BA program comprised seven sessions, with outcomes assessed at multiple time points.
- Primary outcome: Beck Depression Inventory-II (BDI-II) scores; secondary outcomes: anxiety, quality of life, spirituality, behavioral activation, value, and pain.
Main Results:
- The study is the first to assess BA's effectiveness in advanced cancer patients with depression.
- Analysis of variance (ANOVA) will be used to examine changes in BDI-II scores and secondary endpoints between groups over time.
Conclusions:
- Findings will provide evidence for the effectiveness of BA in reducing depression among advanced cancer patients.
- This research may lead to improved mood, life purpose, and value in this vulnerable population.
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