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Updated: Jul 30, 2025
Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
Immunohistochemical expression of the hepatocyte growth factor in chromophobe renal cell carcinoma
Maximilian Erlmeier1, Marie Mikuteit2, Stefanie Zschäbitz3
1Department of Urology, München Klinik Bogenhausen, Munich, Germany.
Background:
The prognostic value of Hepatocyte growth factor (HGF) in non-clear cell renal cell carcinoma (RCC) is still unclear. The aim of this study is to evaluate the prognostic impact of HGF expression in a large cohort of chromophobe RCC (chRCC).
Methods:
Patients who underwent renal surgery due to chRCC were recruited. Clinical data was retrospectively evaluated. Tumor specimen were analyzed for HGF expression by immunohistochemistry.
Results:
81 chRCC patients were eligible for analysis, thereof 37 (45.7%) patients were positive for HGF. No significant associations were found for HGF expression and clinical attributes in patients with chRCC. Kaplan-Meier analysis revealed no differences in 5-year overall survival (OS) for patients with HGF- compared to HGF+ tumors (95.0% versus 90.9%; p = 0.410).
Conclusions:
In chRCC HGF expression is not associated with parameters of aggressiveness or survival.
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