The Aryl Hydrocarbon Receptor, Epigenetics and the Aging Process
S Abudahab1, E T Price, M G Dozmorov
1Sara Abudahab, Smith Building, 410 North 12th Street, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298-0533, USA.
The Journal of Nutrition, Health & Aging
|May 12, 2023
Summary
The aryl hydrocarbon receptor (AhR) plays a role in aging and longevity. Moderate induction of AhR may promote healthspan and longevity by regulating metabolism and interacting with epigenetic aging.
Area of Science:
- Molecular Biology
- Gerontology
- Toxicology
Background:
- The aryl hydrocarbon receptor (AhR) is a transcription factor involved in xenobiotic metabolism.
- Recent studies suggest AhR influences aging and longevity.
- Compounds like resveratrol and quercetin, known AhR ligands, extend lifespan in model organisms.
Purpose of the Study:
- To review AhR biology concerning aging.
- To identify AhR ligands with anti-aging potential.
- To explore the link between AhR, epigenetic aging, and longevity.
Main Methods:
- Literature review of AhR biology and aging.
- Analysis of publicly available datasets integrating AhR target genes and epigenetic aging.
- Identification of potential anti-aging AhR ligands.
Main Results:
- AhR-driven xenobiotic metabolism gene expression in old age may enhance longevity and healthspan.
- Liver-specific AhR target genes are significantly enriched among genes affected by epigenetic aging.
- A potential interplay between AhR and epigenetic aging processes was identified.
Conclusions:
- Moderate AhR induction may offer benefits for longevity and healthspan.
- The interaction between AhR and epigenetic aging warrants further investigation.
- Non-toxic AhR ligands should be explored for promoting healthspan and longevity.
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