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Milan Mohammad1, Zakaria Alaoui-Ismaili1, Lone Baandrup2

  • 1Biomedicinsk Institut, Københavns Universitet.

Ugeskrift for Laeger
|May 12, 2023
PubMed
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Olanzapine depot injections can cause a rare side effect called post-injection delirium/sedation syndrome (PDSS). This case report highlights the importance of monitoring patients for this adverse reaction after administration.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Medicine

Background:

  • Olanzapine depot is a long-acting injectable antipsychotic used for schizophrenia treatment.
  • Post-injection delirium/sedation syndrome (PDSS) is a rare but serious adverse event associated with olanzapine depot.
  • PDSS is characterized by acute onset of delirium and/or sedation following injection.

Observation:

  • A case report details a 38-year-old male experiencing PDSS symptoms post-olanzapine depot administration.
  • The patient developed delirium and sedation shortly after receiving the intramuscular injection.
  • Clinical monitoring is crucial for identifying early signs of PDSS.

Findings:

  • The case confirms the association between olanzapine depot and PDSS.
  • Prompt recognition of PDSS symptoms is vital for patient safety.

Related Experiment Videos

  • Vitals monitoring and timely medical intervention are key management strategies.

    • Implications:

    • Healthcare providers must be vigilant for PDSS in patients receiving olanzapine depot.
    • A mandatory observation period of at least three hours post-injection is recommended.
    • Awareness and adherence to monitoring protocols can mitigate PDSS risks.