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Updated: Jul 30, 2025
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Deep brain stimulation in Parkinson disease with valosin-containing protein gene mutation
Yoon Seob Kim1, Don Gueu Park1, Min Seung Kim1,2
1Department of Neurology, Ajou University School of Medicine, Suwon-si, South Korea.
Background And Purpose:
Mutations in the gene encoding valosin-containing protein (VCP) are related to myriad medical conditions, including familial amyotrophic lateral sclerosis, inclusion body myopathy, and frontotemporal dementia. There are several reports of a link between these mutations and early onset Parkinson disease (PD).
Case Description:
We report a 53-year-old PD patient with VCP mutation who later developed motor complications, thus receiving subthalamic nucleus deep brain stimulation (DBS) at the age of 56 years. However, myopathy emerged 1.5 years after surgery.
Conclusions:
With the phenotype variability of VCP, DBS should be carefully evaluated, considering the possible unfavorable long-term outcomes due to other symptoms of this mutation.
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